Posted: July 4, 2023

Cyclobenzaprine Use During Pregnancy

Cyclobenzaprine Use During Pregnancy

During pregnancy, this medication should be used only when clearly needed. In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at FDA-1088 or at /medwatch. Drowsiness, dizziness, dry mouth, constipation, or tiredness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Therefore, nursing mothers should use cyclobenzaprine with caution (2).

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Do not use in larger or smaller amounts or for longer than recommended. Older adults may be more sensitive to the effects of this medicine. Adding plans allows you to compare formulary status to other drugs in the same class. Ell your doctor if your condition lasts after 2 to 3 weeks or if it gets worse. What to Expect supports Group Black Opens a new window and its mission to increase greater diversity in media voices and media ownership. Group Black’s collective includes Essence Opens a new window, The Shade Room Opens a new window and Naturally Curly Opens a new window.

Precautions Of Cyclobenzaprine Use While Breastfeeding

Five categories – A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy. Sometimes, muscle relaxants like cyclobenzaprine flexeril and antidepressants are used “off-label” to treat conditions they’re not approved for, such as fibromyalgia. It will help avert any adverse effect of the drug on your well-being and infant development.

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During the test, the animals were given 20 times more than the required dose. In spite of this, no severe effects were seen on the pregnant animals. Category B medicines are medicines that are studied on animals and show no adverse effects. During pregnancy, the lady faces discomfort from muscle-related issues.

Use of Flexeril with any of these medications can lead to the potentially life-threatening serotonin syndrome. The Journal of Maternal-Fetal and Neonatal Medicine publishes a case wherein a baby was born in respiratory distress and experiencing pulmonary hypertension after the mother took Flexeril during pregnancy. The report indicates that the use of Flexeril in late pregnancy may lead to early ductal closure of the heart in utero. Flexeril is technically deemed safe during all three trimesters, as there is not enough evidence or controlled studies saying otherwise. If you do have to use Flexeril while pregnant, do so only under the direction of a medical professional and in the lowest doses for as short a time as possible. Follow all directions on your prescription label and read all medication guides or instruction sheets.


In addition to the physiologic changes that occur in the mother during pregnancy, one must also consider the impact of pharmacotherapy in the developing fetus. Many small, lipid-soluble, non-polar molecules readily cross the placenta via passive diffusion, whereas larger polar molecules do not. (Plonait 2004) The point during pregnancy at which the exposure to the pharmaceutical occurs is also important. Early in pregnancy, there may be an “all or none” response where the pregnancy may either terminate or continue normally.

  • However, there is limited data on the safety of Flexeril during pregnancy in human studies.
  • During pregnancy, the lady faces discomfort from muscle-related issues.
  • The drug belongs to category B of the FDA classification system for pregnancy safety, meaning that it has not been studied in pregnant women but has been found to be safe in animals.
  • Flexeril should most likely be avoided by nursing women; however, your doctor will decide whether you can take Flexeril if you are nursing 1.
  • But it can also cause various side effects, including drowsiness, dizziness, and dry mouth.

Data are conflicting but generally support the safety of NSAIDs in the first two trimesters; (Daniel 2014, Damase-Michel 2014) however recommendations and practice patterns are varied. We do not endorse the practice of routine pregnancy testing in women of childbearing age not known to be pregnant prior to the administration of NSAIDs. Muscle relaxants like cyclobenzaprine, are not recommended for people 65 years or older and there are two reasons for this. If you are suffering from muscle pain during pregnancy, you might be wondering what your options are besides taking muscle relaxers. While muscle relaxers are known to be effective, there are some concerns about their safety during pregnancy. Fortunately, there are several alternatives that you could consider to ease your pain and discomfort.

Flexeril and pregnancy: is it safe to use?

Most vital organs form between 3 and 8 weeks gestation, so exposures that occur during this time have the potential to cause significant structural malformations. Exposures later in pregnancy may have a greater impact on fetal growth. Medication use near term can also impact the neonate following delivery. For example, maternal use of opioid analgesics near term can cause respiratory depression in the neonate and non-steroidal anti-inflammatory drugs (NSAIDs) may cause premature closure of the ductus arteriosus. Additionally, the duration of exposure may be clinically relevant, as occurs when prolonged use of opioid analgesics results in neonatal abstinence syndrome. (Brent 1995, Tolia 2015) Finally, during the postpartum period, providers should inquire as to whether the infant is being breast-fed and investigate whether the medication is excreted in the breast milk.

As a result, there could be risks to the fetus if a pregnant woman takes it. Muscle spasms and back pain are common while pregnant, and Flexeril (cyclobenzaprine) is a muscle relaxant. This medicine will add to the effects of alcohol and other CNS medicines that slow down the nervous system, possibly causing drowsiness. Cyclobenzaprine causes some people to have blurred vision or drowsiness, dizziness, or less alertness of the senses than normal.